Iowa St vs. Colorado Football Prediction & Odds - Oct. 11

placeholder image

The No. 22 Iowa State Cyclones (5-1) square off against a conference opponent when they visit the Colorado Buffaloes (2-4) on Saturday, October 11, 2025 at Folsom Field in a Big 12 battle.

Watch college football live without cable. Stream ACC, SEC, ESPN and more with Fubo. What is Fubo? Fubo is a streaming service that gives you access to your favorite live sports and shows on demand. Sign up today and start watching college football games now.

Iowa State vs. Colorado Matchup Info

  • Game date: Saturday, October 11, 2025
  • Game time: 3:30 p.m. ET
  • Location: Boulder, Colorado
  • Venue: Folsom Field
  • TV channel: ESPN
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Stop missing games and start streaming college football right now on Fubo.

Iowa State vs. Colorado Odds and Prediction

  • Spread favorite: Cyclones (-2.5)
  • Moneyline: Cyclones (-137), Buffaloes (+116)
  • Total: 52 points
  • Pick ATS: Iowa State (-2.5)
  • Pick OU: Under (52)
  • Prediction: Iowa State 29, Colorado 20

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

Looking for officially licensed gear? Fanatics has jerseys, hats, apparel, memorabilia, trading cards, collectibles and more.

Iowa State vs. Colorado Betting Records and Insights

  • Iowa State has compiled a 3-2-1 ATS record so far this year.
  • Colorado has put together a 3-3-0 ATS record so far this year.
  • The Cyclones have covered the spread twice when favored by 2.5 points or more this season (in four opportunities).
  • The Buffaloes have been an underdog by 2.5 points or more four times this year, and covered the spread in one of those games.
  • A total of three out of six Iowa State games this season have hit the over.
  • So far this year, two Colorado games have hit the over.

Sponsored Content

Sponsored Content