Iowa St vs. BYU Football Prediction & Odds - Oct. 25

Big 12 foes meet when the Iowa State Cyclones (5-2) and the No. 11 BYU Cougars (7-0) play on Saturday, October 25, 2025 at Jack Trice Stadium.

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Iowa State vs. BYU Matchup Info

  • Game date: Saturday, October 25, 2025
  • Game time: 3:30 p.m. ET
  • Location: Ames, Iowa
  • Venue: Jack Trice Stadium
  • TV channel: FOX
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Iowa State vs. BYU Odds and Prediction

  • Spread favorite: Cyclones (-2.5)
  • Moneyline: Cyclones (-136), Cougars (+114)
  • Total: 48.5 points
  • Pick ATS: BYU (+2.5)
  • Pick OU: Under (48.5)
  • Prediction: BYU 25, Iowa State 22

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Iowa State vs. BYU Betting Records and Insights

  • Iowa State has put together a 3-3-1 ATS record so far this year.
  • BYU has compiled a 5-2-0 ATS record so far this year.
  • The Cyclones have covered the spread twice this season (2-2-1 ATS) when playing as at least 2.5-point favorites.
  • The Cougars have won their only game this season when playing as at least 2.5-point underdogs.
  • So far this season, three of Iowa State's seven games have hit the over.
  • In BYU's seven contests this year, the combined scoring has gone over the point total three times.

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